A variety of neurophysiological effects are associated with this form of treatment. A manipulative therapy often provides an immediate effect. A stimulus that happens by manipulation is aimed at the nerve receptors (mechanoreceptors) activates and inhibits pain impulses (nociceptors). As mentioned above, chiropractors work mainly with the nervous system. Research has shown that joint correction treatment reduces pain and increases pain tolerance. Moreover, it observed immediate effects on the autonomic nervous system that changes in blood pressure, changes in pupil diameter and skin temperature.